CLINICS is an electronic journal that publishes peer-reviewed articles in continuous flow, of interest to clinicians and researchers in medical and biomedical sciences.
Edited by: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HC-FMUSP)
Journal Information

Last published articles

Original articles
Delayed diagnosis and increased mortality risk: Assessing the effects of the COVID-19 pandemic on breast cancer recurrence
Lindson Mühlmann, Franklin Fernandes Pimentel, Daniel Guimarães Tiezzi, Hélio Humberto Angotti Carrara, Jurandyr Moreira de Andrade, Francisco José Candido dos Reis
Highlights

  • COVID-19 profoundly affected global healthcare including breast cancer management.

  • The pandemic delayed recurrence diagnosis and increased post-recurrence mortality.

  • Strategies for cancer patients' follow-up during health crises need improvements.

Full text access
Available online 1 January 2024
Original articles
Evaluation of HLA-DQ2 and HLA-DQ8 haplotypes in patients with endometriosis, A case-control study
Marina P. Andres, Alessandra Peloggia, Henrique M. Abrao, Thais F. Magalhaes, João Siufi Neto, Mauricio Simões Abrão
Highlights

  • Celiac disease and endometriosis share inflammatory markers and pathophysiology.

  • HLA-DQ2 and/or HLA-DQ8 were similar between the control and endometriosis groups.

  • Anti- transglutaminase igA was similar between the control and endometriosis groups.

  • HLA-DQ2 and DQ8 had no difference in age, symptoms, endometriosis stage or location.

Full text access
Available online 1 January 2024
Original articles
Cross-cultural adaptation of the Scale of Perception of Respect for and Maintenance of the Dignity of the Inpatient (CuPDPH) to Brazilian Portuguese and its psychometric properties—A multicenter cross-sectional study
Pablo Eduardo Pereira Dutra, Laiana Azevedo Quagliato, Filipe Terra Curupaná, Letícia Zangirolami Peres, Victoria Luiza Pacini, Claudia Regina Menezes da Silva, Juliana Seixas Garcia, Beatriz Campillo Zaragoza, Antonio Egidio Nardi
Highlights

  • Despite their importance, dignity and respect are woefully undefined, and often cast aside, which is reflected by the scarcity of in-depth studies.

  • Brazilian patients feel respected, but when it comes to consideration and integrity, it is nothing short of heartbreaking.

  • Brazilian health professionals do not ask their patients whom they would like to share information with. And this demands our utmost attention.

  • A sting of disrespect and affronts to our dignity seldom escape our notice.

  • The Scale of Perception of Respect for and Maintenance of the Dignity of the Inpatient sheds light on this aspect of human interaction.

Full text access
Available online 1 January 2024
Original articles
Effect of 3D laparoscopy versus traditional laparotomy on serum tumor markers and coagulation function in patients with early-stage endometrial cancer
Hailong Chen, Dechang Xu, Ying Yu, Jing Huang, Qian Zhou, Qi Wang
Highlights

  • 3D laparoscopic surgery for early-stage EC seems to be more effective than traditional laparotomy.

  • 3D laparoscopic surgery for early EC can attenuate the inflammatory response and damage to immune function, foster urinary function recovery, and enhance the quality of life.

  • 3D laparoscopic surgery for early EC impacts the patient's coagulation function, necessitating vigilant prevention and management of thrombotic events in clinical settings.

Full text access
Available online 1 January 2024
Review articles
Multidisciplinary team for patients with neurocutaneous syndromes: The little discussed importance of dentistry
Marcos Roberto Tovani-Palone, Filippo Bistagnino, Pritik A. Shah
Highlights

  • The inclusion of dentists in multidisciplinary teams for patients with neurocutaneous syndromes is essential, both on an outpatient and hospital basis.

  • Interestingly, dentistry can play a relevant role in the early diagnosis and differential diagnosis of patients with neurocutaneous syndromes.

  • More research in this area is needed.

Full text access
Available online 1 January 2024
Original articles
Prolonged survival after thoracic metastasectomy in patients with nonseminomatous testicular cancer
Jaqueline Schaparini Fonini, Pedro Henrique Xavier Nabuco de Araujo, Paula Duarte D'Ambrosio, Juliana Vieira de Oliveira Salerno, Pedro Prosperi Desenzi Ciaralo, Ricardo Mingarini Terra, Paulo Manuel Pêgo-Fernandes
Highlights

  • Few studies have examined outcomes after intrathoracic metastasectomy for nonseminomatous testicular germ cell tumors.

  • Integration of local and systemic therapies yields favorable outcomes with low morbidity and mortality.

  • Surgical management should be considered after chemotherapy, as histology prediction for metastatic lesions remains challenging.

  • This study highlights the importance of aggressive surgical approaches in improving long-term survival in young patients with testicular NSGCT.

Full text access
Available online 1 January 2024
Review articles
Pharmacological treatment for obstructive sleep apnea: A systematic review and meta-analysis
Maria Luísa Nobre, Ayane Cristine Alves Sarmento, Priscila Farias de Oliveira, Felipe Ferreira Wanderley, José Diniz Júnior, Ana Katherine Gonçalves
Highlights

  • Obstructive sleep apnea affects one billion people worldwide and is associated with cardiometabolic risk and cognitive impairment.

  • Drug therapy for the management of sleep apnea has been investigated, but no robust evidence that supports its benefits has been found to date.

  • The combination of noradrenergic and antimuscarinic drugs shows promising results.

Full text access
Available online 1 January 2024
Original articles
Expression and clinical significance of miR-141-5p as a biomarker in the serum of patients with early spontaneous abortion
XiaoQun Che, Xiao Wang, LiLian Wang, LiHua Xu, Lin Zou, TianZhong Ma, Bi Chen
Highlights

  • Correlation analysis of miR-141-5p and serum β-HCG, P4 and E2 levels in patients with ESA.

  • miR-141-5p as a diagnostic biomarker for ESA.

  • β-HCG, P4 and E2 levels.

Full text access
Available online 1 January 2024
Original articles
Relationship between semen parameters, serum InhB, and INSL-3 levels, and the degree of varicocele
Lei Liu, WenJie Huang, KeBing Luo, YiZhou Zeng, YunHao Shao, ZongMin Long
Highlights

  • Serum INSL-3 in patients with varicocele decreases with the severity of the disease.

  • Serum INSL-3 is positively correlated with total sperm count.

  • Serum InhB is associated with semen volume, concentration, and total sperm.

  • Serum InhB and INSL-3 levels could distinguish the degree of varicocele.

Full text access
Available online 1 January 2024
Clinics

Are you a health professional able to prescribe or dispense drugs?

Cookies policy
To improve our services and products, we use cookies (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here.