CLINICS is an electronic journal that publishes peer-reviewed articles in continuous flow, of interest to clinicians and researchers in medical and biomedical sciences.
Edited by: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HC-FMUSP)
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Section Index

Multidisciplinary team for patients with neurocutaneous syndromes: The little discussed importance of dentistry
Marcos Roberto Tovani-Palone, Filippo Bistagnino, Pritik A. Shah

  • The inclusion of dentists in multidisciplinary teams for patients with neurocutaneous syndromes is essential, both on an outpatient and hospital basis.

  • Interestingly, dentistry can play a relevant role in the early diagnosis and differential diagnosis of patients with neurocutaneous syndromes.

  • More research in this area is needed.

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Available online 1 January 2024
Pharmacological treatment for obstructive sleep apnea: A systematic review and meta-analysis
Maria Luísa Nobre, Ayane Cristine Alves Sarmento, Priscila Farias de Oliveira, Felipe Ferreira Wanderley, José Diniz Júnior, Ana Katherine Gonçalves

  • Obstructive sleep apnea affects one billion people worldwide and is associated with cardiometabolic risk and cognitive impairment.

  • Drug therapy for the management of sleep apnea has been investigated, but no robust evidence that supports its benefits has been found to date.

  • The combination of noradrenergic and antimuscarinic drugs shows promising results.

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Available online 1 January 2024
Gastric adenocarcinoma and periodontal disease: A systematic review and meta-analysis
Francisco José Nunes Aguiar, Fabrício dos Santos Menezes, Marcela de Araújo Fagundes, Gisele Aparecida Fernandes, Fabio de Abreu Alves, João Goncalves Filho, Maria Paula Curado

  • Patients presenting periodontal disease increased the risk of developing gastric adenocarcinoma by 17 %.

  • The association remained regardless of the diagnostic method for periodontal disease, i.e., clinical examination and self-report.

  • Moreover, Asian patients with periodontal disease had a higher risk of having gastric adenocarcinoma than American and European patients.

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Available online 1 January 2024
Does bisphenol A (BPA) participates in the pathogenesis of Polycystic Ovary Syndrome (PCOS)?
Lorena Ana Mercedes Lara Urbanetz, José Maria Soares Junior, Gustavo Arantes Rosa Maciel, Ricardo dos Santos Simões, Maria Cândida Pinheiro Baracat, Edmund Chada Baracat
Clinics. 2023;78C:100310

  • Bisphenola A (BPA) is an endocrine disruptor widely investigated as a possible environmental contributor to the pathogenesis of Polycystic Ovary Syndrome (PCOS).

  • Due to its structural similarity with the Estrogen molecule (E2), it acts as a xenoestrogen, binding to genomic and non-genomic estrogen receptors, causing metabolic and hormonal changes that lead to PCOS (hyperandrogenism, insulin resistance, hyperinsulinemia, obesity, atherogenic dyslipidemia, anovulation, and ovarian cysts).

  • The aim and of this review were to present the mechanisms of bisphenol A participation in the pathogenesis of Polycystic Ovary Syndrome.

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Epigenetics, hypersensibility and asthma: what do we know so far?
Douglas da Silva Lima, Rahuany Velleda de Morais, Ciliana Rechenmacher, Mariana Bohns Michalowski, Marcelo Zubaran Goldani
Clinics. 2023;78C:100296

  • Epigenetics, hypersensibility and asthma: what do we know so far?

  • Asthma can be triggered from epigenetic changes.

  • Early life exposures can contribute to the development and exacerbation of asthma.

  • DNA methylation profile of certain genes is related to asthma and allergy.

  • Nasal epithelium samples have shown promise as a tissue for studying DNA methylation changes related to asthma.

  • To find biomarkers and standardized assays to advance the field of epigenetics in respiratory disorders are still a challenge.

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Diagnostic performance of microRNA-29a in active pulmonary tuberculosis: a systematic review and meta-analysis
Xiaoying Li, Yuehong Xu, Pu Liao
Clinics. 2023;78C:100290

  • A meta-analysis was applied to analyze the performance of miRNA-29a in diagnosing active pulmonary tuberculosis.

  • miRNA-29a can be used as a biomarker for the diagnosis of active tuberculosis.

  • Tuberculosis burden and sample type of miRNA-29a may influence its diagnostic performance.

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CT radiomics for prediction of microvascular invasion in hepatocellular carcinoma: A systematic review and meta-analysis
Hai-ying Zhou, Jin-mei Cheng, Tian-wu Chen, Xiao-ming Zhang, Jing Ou, Jin-ming Cao, Hong-jun Li
Clinics. 2023;78C:100264

  • CT radiomics could preoperatively predict MVI in HCC with an AUC of 0.87.

  • Radiomics model based on 3D tumor segmentation, and deep learning model can be superior to predict MVI.

  • Reproducibility of current radiomics models for clinical application may be uncertain.

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Driving force of deteriorated cellular environment in heart failure: Metabolic remodeling
Lu Fan, Chenchen Meng, Xiaoming Wang, Yunjiao Wang, Yanyang Li, Shichao Lv, Junping Zhang
Clinics. 2023;78C:100263

  • Improving the cellular environment is expected to further optimize the management of HF.

  • Metabolic remodeling is the driving force of deteriorated cellular environment in HF.

  • Targeting impaired energy provision is of great potential in the treatment of HF.

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Mesenchymal stem cells in lung diseases and their potential use in COVID-19 ARDS: A systematized review
Bruna Benigna Sales Armstrong, Juan Carlos Montano Pedroso, José da Conceição Carvalho, Lydia Masako Ferreira
Clinics. 2023;78C:100237

  • None of the analized studies related serious adverse effects or toxicity to IV ASCs administration.

  • This review suggests optimism in IV ASCs for lung damage in severe COVID-19 ARDS.

  • Further studies on IV ASCs in COVID-19 are needed for standard dosage.

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Efficacy, safety, and potential industry bias in using deoxycholic acid for submental fat reduction ‒ A systematic review and meta-analysis of randomized clinical trials
Gabriel Santiago Giuglio Inocêncio, Daniela Meneses-Santos, Marcelo Dias Moreira de Assis Costa, Walbert A. Vieira, Vinicius Lima de Almeida, Renata Prata Cunha Bernardes Rodrigues, Sigmar de Mello Rode, Luiz Renato Paranhos
Clinics. 2023;78C:100220

  • Deoxycholic acid is effective in submental fat reduction for both clinician and patient-related outcomes.

  • Well-tolerated side-effects were observed in Deoxycholic acid groups.

  • All eligible randomized trials showed a potential industry bias.

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