Section Index

Left atrial appendage occlusion is a surgical procedure considered as an alternative for populations with contraindications or failure of anticoagulation.

Based on the studies, it was evaluated that, among the consensual metrics (CHADS-VASC and HAS-BLED), the degree of thromboembolic risk and bleeding used was variable, not clarifying the profile of patients who would benefit from the occlusion procedure.

Most of the studies evaluated are non-inferior, comparing the occlusion of the atrial appendage of patients on anticoagulation with vitamin K inhibitors, with no contraindication to the use of this group of drugs. There are ongoing studies, with data to be published with the use of new oral anticoagulants (direct inhibitors), to compare the safety of patients undergoing atrial appendage occlusion.

There is also a lack of evidence related to the occlusion devices, especially regarding long-term use data, since when positioned, it can cause anatomical and physiological changes. Also, there is more than one model of the device with differences between them, suggesting the need for comparative studies.

Melatonin had beneficial effects on outcomes in assisted reproductive technologies, but it had no influence on pregnancy.

Melatonin had beneficial effects such as the improvement in the fertilization rate.

Melatonin has a beneficial effect on the formation of mature oocytes (MII).

Flunarizine Hydrochloride combined with TCM notably enhances migraine management.

Flunarizine Hydrochloride and TCM improve TCM scores, endothelin, NRS and VAS scores.

Flunarizine Hydrochloride combined with TCM reduces headache frequency and duration.

Standardized protocols are crucial to understand TCM's role in migraine management better.

This meta-analysis aimed to evaluate the impact of art therapy on reducing anxiety symptoms among children and adolescents. A comprehensive search was conducted across several databases, including PubMed, Web of Science, Embase, PsychINFO, The Cochrane Library, CNKI, and Wan Fang Data, resulting in the inclusion of six studies with a total of 422 participants. The findings demonstrated a significant decrease in anxiety symptoms through art therapy interventions, with a Standardized Mean Difference (SMD) of -1.42, 95% Confidence Interval (-2.33, -0.51), p < 0.002. This indicates that art therapy is an effective method for treating anxiety in this demographic. Moreover, the analysis revealed that art therapy had a more pronounced effect on state anxiety than on trait anxiety, suggesting that art therapy may be particularly beneficial in helping children and adolescents manage anxiety in specific situations. These insights underscore the importance of integrating art therapy into mental health care, especially for managing anxiety among young individuals, and have significant implications for clinical practice and policy making.

Acute ischaemic stroke is becoming a major public health concern.

The nationwide or health organization registry databases were included.

Bridging therapy remains the standard treatment until more data are available.

Visceral crisis in metastatic breast cancer is associated with a dismal prognosis.

There is a lack of objective clinical criteria in the definition of visceral crisis.

Visceral crisis management is currently based on limited retrospective evidence and expert opinions.

The role of chemotherapy as the treatment of choice for visceral crisis has been recently questioned.

There is a global increase in childhood myopia and current treatments are limited.

LLRL non-invasive therapy shows promise in myopia control.

LLRL is promising and requires further studies for standardization and safety.

Autism Spectrum Disorder (ASD) is a heterogeneous neurodevelopmental disorder.

Autism spectrum disorder has a significant impact on the patient and their family.

To provide adequate advice is to carry out screening and diagnosis correctly and accurately.

Screening test must be applied, M-CHAT-R/F is recommended.

For diagnosis CARS and ADOS are the most recommended tools.

Impulse Oscillometry (IOS) can be used to analyze lung resistance and reactance in patients with PAH.

Patients with PAH show increased resistance and pulmonary reactance compared to healthy individuals.

The IOS findings showed a good correlation with the spirometric variables.