CLINICS is an electronic journal that publishes peer-reviewed articles in continuous flow, of interest to clinicians and researchers in medical and biomedical sciences.
Edited by: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HC-FMUSP)
Journal Information

Section Index

Noninvasive assessment of liver fibrosis can predict clinical outcomes at late follow-up after a sustained virological response in HCV patients?
Taisa Grotta Ragazzo, Patricia Momoyo Yoshimura Zitelli, Daniel F. Mazo, Claudia P. Oliveira, Flait José Carrilho, Mário Guimarães Pessoa
Highlights

  • Transient elastography is the best accepted noninvasive technique for evaluating fibrosis in patients with HCV.

  • The variation in the LSM measurement can demonstrate the risk of liver-related events.

  • The presence of LSM ≥19 kPa 6 months after treatment increases the risk of liver-related events.

Full text access
Available online 1 January 2024
Effects of Apatinib combined with Temozolomide on levels of sPD-1 and sPD-L1 in patients with drug-resistant recurrent glioblastoma
Ren Zhao Kuang, Jun Wang, Yuan Chuan Wang, Xiao Ping Tang
Highlights

  • Apatinib combined with TMZ is effective for recurrent GB.

  • Apatinib combined with TMZ can reduce the levels of sPD-1 and sPD-L1.

Full text access
Available online 1 January 2024
Keap1/Nrf2 signaling pathway participating in the progression of epilepsy via regulation of oxidative stress and ferroptosis in neurons
Dandan Wang, Yunmei Cui, Fan Gao, Weiwei Zheng, Jinzi Li, Zhemin Xian
Highlights

  • Role of the Keap1/Nrf2 pathway in epilepsy.

  • Effects of the Keap1/Nrf2 pathway on ferroptosis and oxidative stress in neuronal cells.

  • Effect of Keap1/Nrf2 pathway on neuronal cell activity in epileptic rats.

Full text access
Available online 1 January 2024
Prognostic nomogram based on pre-treatment HALP score for patients with advanced non-small cell lung cancer
Shan Gao, Qin Huang, Suosu Wei, Yanru Lv, Yanyan Xie, Yanrong Hao
Highlights

  • The authors created a new predictive model based on HALP scores in progressive NSCLC.

  • HALP score may be an accurate prognostic factor for PFS and OS in advanced NSCLC.

Full text access
Available online 1 January 2024
Development and validation of prognostic nomograms for adult with papillary renal cell carcinoma: A retrospective study
Qingxiang Guo, Sai Li, Jiawei Zhu, Zewei Wang, Zhen Li, Junqi Wang, Rumin Wen, Hailong Li
Highlights

  • Radiotherapy benefits prognosis in papillary renal cell carcinoma.

  • A precise nomogram predicts survival in pRCC patients.

  • External validation confirms the nomogram's applicability to Chinese pRCC.

Full text access
Available online 1 January 2024
Blood transfusion is correlated with elevated adult all-cause mortality and cardiovascular mortality in the United States: NHANES 1999 to 2018 population-based matched propensity score study
Jie Shi, Min Meng, Rina Sa, Lijun Yu, Yali Lu, Bei Gao
Highlights

  • Blood transfusion significantly impacts long-term all-cause and cardiovascular mortality in the US population.

  • After propensity score-matching, the risk of all-cause mortality increased by 78 % with blood transfusion, and the risk of cardiovascular mortality increased by 102 %.

  • The effective management of blood transfusion in the general population may be beneficial.

Full text access
Available online 1 January 2024
Physicians’ attention to patients’ communication cues can improve patient satisfaction with care and perception of physicians’ empathy
Carlos Frederico Confort Campos, Clarice Rosa Olivo, Milton de Arruda Martins, Patricia Zen Tempski
Highlights

  • • Patient-doctor communication relates to patient satisfaction and perceived empathy.

  • • Patients asking questions was linked to poor satisfaction and empathy perceptions.

  • • Doctor's use of negative communication skills related to worse rapport with patients.

  • • Satisfaction and empathy are positively linked to patient affective expression.

  • • Doctors providing advice/suggestions positively correlated to patient satisfaction.

Full text access
Available online 1 January 2024
TRPC5 channel participates in myocardial injury in chronic intermittent hypoxia
Mengmeng Wang, Wen Wen, Yulan Chen, Sharezati Yishajiang, Yu Li, Zhiqiang Li, Xiangyang Zhang
Highlights

  • The study developed an animal model of chronic intermittent hypoxia (CIH).

  • CIH activated oxidative stress (OS) inhearts, increased ROS, and up-regulated TRPC5.

  • TRPC5 is related to OS, the imbalance of Ca2+ homeostasis, and myocardial injury.

Full text access
Available online 1 January 2024
Association of log odds of positive lymph nodes with survival in patients with small cell lung cancer: Results from the SEER database
Ting Gao, Yingxuan Chang, Hongmei Yue
Highlights

  • The prognosis of patients with SCLC can be predicted by their LN status.

  • The authors aimed to assess the correlations between SCLC survival and LNR, pLNs, LODDS.

  • LODDS may be better than other LN assessment tools at predicting survival in SCLC.

Full text access
Available online 1 January 2024
The mechanism of mitochondrial metabolic gene PMAIP1 involved in Alzheimer's disease process based on bioinformatics analysis and experimental validation
Yingchun Ling, Lingmin Hu, Jie Chen, Mingyong Zhao, Xinyang Dai
Highlights

  • PMAIP1 may be a potential biomarker for Alzheimer's Disease.

  • PMAIP1 has a certain pro-apoptotic effect.

  • PMAIP1 is participate in hippocampal neuron damage by regulating mitochondrial function.

Full text access
Available online 1 January 2024
Clinics

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