CLINICS is an electronic journal that publishes peer-reviewed articles in continuous flow, of interest to clinicians and researchers in medical and biomedical sciences.
Edited by: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HC-FMUSP)
Journal Information

Section Index

Evaluation of the RAPID score as a predictor of postoperative morbidity and mortality in patients undergoing pulmonary decortication for stage III pleural empyema
Danilo Caribé Carneiro, Paula Duarte D'Ambrosio, Alessandro Wasum Mariani, Jaqueline Schaparini Fonini, Gabriela Ketherine Zurita Aguirre, João Pedro Carneiro Leão, Aurelino Fernandes Schmidt Júnior, Eihab O. Bedawi, ... Paulo Manuel Pêgo-Fernandes
Highlights

  • This study establishes a strong correlation between the RAPID score and 3-month mortality in patients undergoing lung decortication for pleural empyema.

  • Patients were stratified into low, medium, and high-risk groups based on the RAPID score, demonstrating that this approach can be valuable in identifying patients with a higher likelihood of complications. This can inform treatment planning and post-operative monitoring.

  • While the results suggest a strong correlation, prospective studies are needed to fully validate the use of the RAPID score in this population. This underscores the importance of future clinical research to enhance the selection of the initial treatment for patients with pleural empyema.

Full text access
Available online 1 January 2024
Comparative analysis of primary health care attributes between children under and over 3 years of age using the primary care assessment tool
Luciana Harumi Miranda Omori, Deoclecio Avigo, Itamar de Souza Santos, Gustavo Diniz Ferreira Gusso, Maria Teresa Bechere Fernandes
Highlights

  • Government programs primarily focus on early childhood.

  • Primary Care services tend to be better for children under three years old.

  • New programs are needed to provide follow-up care for children beyond early childhood.

Full text access
Available online 1 January 2024
Patients who received sleeve gastrectomy have lower plasma osteopontin levels than those who did not
Doğan Öztürk, Arzu Or Koca, Müge Keskin, Bülent Öztürk, Esra Fırat Oğuz, Turan Turhan, Hakan Buluş
Highlights

  • Obesity causes higher plasma OPN levels and higher expression of OPN in adipose tissue.

  • OPN and HGF are promising biomarkers that can be used to detect problems related to obesity.

  • Patients in the early post-SG period had lower plasma OPN and similar plasma HGF compared to nonsurgical patients.

  • After bariatric surgery, despite down-regulation of local OPN expression in adipose tissue, a significant increase in circulating OPN concentrations occurs

Full text access
Available online 1 January 2024
Surgical complications in the first and second semesters of the general surgery medical residence. A study of 14063 cases
Bruno Henrique Alvarenga, Izabel Cristina Rios, Francisco de Salles Collet e Silva, Edivaldo Massazo Utiyama
Highlights

  • Surgical complications increase after the entry of new resident doctors.

  • Second-year resident doctors need more training time.

  • The increase in surgical complications is associated with the entry of new resident doctors, but also with the progression from the first to the second year of the course.

Full text access
Available online 1 January 2024
Polidocanol-foam treatment of varicose veins: Quality-of-life impact compared to conventional surgery
Lissa Severo Sakugawa, Felipe Soares Oliveira Portela, Andressa Cristina Sposato Louzada, Maria Fernanda Cassino Portugal, Marcelo Passos Teivelis, Cynthia de Almeida Mendes, Lucas Lembrança Pinheiro, Marcelo Fiorelli Alexandrino da Silva, ... Nelson Wolosker
Highlights

  • Both polidocanol foam sclerotherapy and conventional surgery had positive impacts on patient quality of life.

  • Conventional surgery promotes greater improvement in patient quality-of-life than sclerotherapy.

  • Post-procedure pain and aesthetic concerns about the legs worsen the efficacy of sclerotherapy.

Full text access
Available online 1 January 2024
A meta-analysis on the efficacy of endoscopic ultrasonography for treatment of pancreatic cancer
Min Xuan, Na Li, Chunyan Wu
Highlights

  • EUS-guided treatment for pancreatic cancer had fewer adverse reactions and a higher success rate.

  • The direct injection of absolute ethanol into the abdominal ganglion exerted the best pain relief effects.

  • US-guided Celiac Plexus Neurolysis (EUS-CPN) relieved and eliminated pain significantly.

Full text access
Available online 1 January 2024
Reduced HDL-cholesterol in long COVID-19: A key metabolic risk factor tied to disease severity
Jamila Al-Zadjali, Amal Al-Lawati, Nafila Al Riyami, Koukab Al Farsi, Najwa Al Jarradi, Ammar Boudaka, Ali Al Barhoumi, Mohsen Al Lawati, ... Jumana Saleh
Highlights

  • Low HDL-C and high ferritin are linked to increased Long-COVID-19 severity.

  • Changes in HDL-C levels, significantly impact Long-COVID-19 progression.

  • Ferritin may exacerbate disease progression by increasing oxidative stress.

  • HDL-C and ferritin levels may serve as markers and therapeutic targets for Long-COVID-19.

Full text access
Available online 1 January 2024
Circ-ABCA1 promotes oxidized low-density lipoprotein-induced inflammation and phenotypic switch in vascular smooth muscle cells
Fang Yu, JiWei Liu, Xiao Wei
Highlights

  • Si-circABCA1 inhibits VMSC malignant proliferation, inflammation, and phenotypic switch.

  • miR-885–5p blocks the promoting effects of circABCA1 on VMSCs.

  • CircABCA1 regulates the miR-885–5p/ROCK2 axis in VMSCs.

  • Knockdown of circABCA1 reduces arterial plaque size and improves inflammation in AS mice.

Full text access
Available online 1 January 2024
Olanzapine as a prophylactic antiemetic for preventing postoperative nausea and vomiting after general anesthesia: A systematic review and meta-analysis
Thiago Ramos Grigio, Hans Timmerman, Angela Maria Sousa, André Paul Wolff
Highlights

  • Olanzapine is identified as a potentially effective prophylactic antiemetic.

  • Olanzapine reduces the incidence of postoperative nausea and vomiting.

  • Olanzapine has few side effects.

Full text access
Available online 1 January 2024
A randomized clinical trial comparing internal and external pessaries in the treatment of pelvic organ prolapse in postmenopausal women: A pilot study
Renato Sugahara Hosoume, Thais Villela Peterson, José Maria Soares Júnior, Edmund Chada Baracat, Jorge Milhem Haddad
Highlights

  • Internal and external pessaries improved the quality of life of women with pelvic organ prolapse.

  • The use of an internal pessary changed the POP-Q stage related to prolapse of the anterior and apical vaginal compartments in women with pelvic organ prolapse.

  • Studies investigating alternative treatments for Pelvic organ prolapse, such as the use of an external pessary, are extremely important.

Full text access
Available online 1 January 2024
Clinics

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